Vol. 2 nº 2 - Apr/May/Jun de 2008
Original Article Páginas: 82 a 90

Subcortical ischemic vascular disease and cognition: a systematic review

Authors Gilberto Sousa Alves1, Carlos Eduardo de Oliveira Alves1, Maria Elisa Lanna1, Denise Madeira Moreira2,3, Eliasz Engelhardt2, Jerson Laks1,4


keywords: neuropsychology, vascular dementia, cerebrovascular disorders, cognition.

Subcortical Ischemic Vascular Disease (SIVD) is underdiagnosed. This review investigates the relationship among SIVD severity, cognitive status and neuroimaging markers. Methods: Cohort, cross-sectional and case control studies were searched on ISI, Medline, Scielo, PsychoInfo and LILACS databases published between 1995 and 2006. Results: The most impaired cognitive domains were executive, attentional and memory retrieval mechanisms. These cognitive features were frequently associated to White Matter Lesions (WML). Conclusions: WML is an independent factor in cognitive decline. However, the threshold for this impact is not yet clearly established.


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