Vol. 16 nº 2 - Apr/May/Jun de 2022
Case Report Páginas: 249 a 252

Lithium Intoxication as a cause of reversible dementia mimicking FDG PET features of Alzheimerâ?Ts disease

Authors Alexandre Motta Mecê1; Vitor Corsaletti Abreu1; Gustavo Manginelli Lamas1; Rafaella do Rosário Tacla1; Thais Benício Minekawa2; Celso Dario Ramos2; Marcio Luiz Figueiredo Balthazar1


keywords: Lithium; Positron Emission Tomography Computed Tomography; Bipolar Disorder.

Rapidly progressive dementia (RPD) is a rare neurological disorder. Drug toxicity is among the differential diagnoses, including the use of lithium, in which an overdosage might cause cognitive dysfunction. Clinical suspicion, laboratory confirmation, and drug interruption are key points in the management of lithium intoxication. We described a 66-year-old female patient under treatment with lithium who developed an RPD associated with parkinsonian symptoms. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) showed an â?oAlzheimer-likeâ?? pattern, while cerebrospinal fluid biomarkers for the disease were negative. There was a significant clinical and radiological improvement after lithium interruption. Lithium intoxication is a potentially reversible cause of RPD, as demonstrated in this case report. Drug discontinuation should be considered even in patients with normal levels of this metal, if cognitive impairment is detected. 18F-FDG PET/CT images may show an â?oAlzheimer-likeâ?? image pattern in acute intoxication and are useful for monitoring these patients.


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